Lab-Grown Testicles Created In Male Fertility Breakthrough

February 21, 2024

These lab-grown organs, cultured from cells sampled from mouse testes, formed small tubules that parallel the sperm-producing seminiferous tubules found in real testicles. Abnormal development or function of the testicles can therefore lead to fertility problems or ambiguous genitalia at birth. In the testis, maturing sperm cells migrate along the convoluted seminiferous tubules, surrounded by nurturing Sertoli cells that support their development. The channels in the lab-grown organoids strongly resembled these intricate tubular networks, lending hope that they too could one day produce sperm. Study authors don’t yet know if the existing model will actually produce sperm cells, but the signs of the beginning of meiosis are promising.

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