Researchers identify key player in cellular response to stress - Chiropractic + Naturopathic Doctor

February 18, 2024

An enzyme called Fic, whose biochemical role was discovered at UT Southwestern more than a dozen years ago, appears to play a crucial part in guiding the cellular response to stress, a new study suggests. Dr. Casey co-led this study with Kim Orth, Ph.D., Professor of Molecular Biology and a Howard Hughes Medical Institute Investigator. The researchers soon discovered that animals ranging from worms to humans also have a Fic enzyme. Dr. Orth added that an uncontrolled cellular stress response and UPR play a role in many diseases including cancer, metabolic syndrome, atherosclerosis, retinal degeneration, and various neurodegenerative disorders. “If we can determine how the ‘stress thermostat’ is set, we could adjust it up or down in various diseases where stress response is a factor,” she said.

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