This exploratory cross-sectional study found a positive association between MRI-defined cervical disc degeneration, disc contour changes, and self-reported NP and between VESC and neck disability. Overall, very few studies have investigated the association between cervical degenerative MRI findings and clinical symptoms. In the current study, we did not find a statistically significant association between the assessed cervical MRI findings and self-reported headaches. To our knowledge, very few studies have investigated the association between cervical MRI findings and headaches. There were also very few patients with moderate or severe cervical MRI findings, and we were therefore unable to explore different thresholds of severity of MRI findings.