This systematic review and network meta-analysis protocol is reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols (PRISMA-P) . The systematic review and network meta-analysis will be reported according to the Preferred Reporting items of Systematic reviews and Meta-Analyses for Network Meta-Analyses (PRISMA-NMA) . After title and abstract screening, 314 systematic reviews were eligible for full-text review, and 85 systematic reviews were included and reported on 442 distinct references to be eligible in the study selection process. Therefore, we will limit our systematic search from January 1st, 2018, to December 2nd, 2022, to ensure the identification of more recent trials. Other sourcesReferences will be added from newer known systematic reviews, not included in the exploratory search and systematic reviews found through CENTRAL [6,7,8, 8,9,10, 21,22,23].